(E/Z)-Locostatin

MedChem Express

(E/Z)-Locostatin [133812-16-5]

10

133812-16-5

Research Use Only

99.52

C14H15NO3

245.27

(E/Z)-Locostatin ((E/Z)-UIC-1005) is a racemic of Locostatin. Locostatin (UIC-1005) is a potent RKIP inhibitor. Locostatin binds Raf kinase inhibitor RKIP protein and disrupts the interaction of RKIP with Raf-1 kinase and G protein-coupled receptor kinase 2. Locostatin inhibits cell proliferation and migration. Locostatin aggravates thioacetamide (HY-Y0698)-induced acute liver failure in mice [1][2][3].

O=C1OC[C@H](CC2=CC=CC=C2)N1C(/C=C/C)=O

-20°C,2°C to 8°C

12352200