(E/Z)-Necrosulfonamide

MedChem Express

(E/Z)-Necrosulfonamide [432531-71-0]

5

432531-71-0

Research Use Only

98.84

C18H15N5O6S2

461.47

(E/Z)-Necrosulfonamide is a racemic compound of Necrosulfonamide (HY-100573). Necrosulfonamide is a necroptosis inhibitor acting by selectively targeting the mixed lineage kinase domain-like protein (MLKL). Necrosulfonamide prevents MLKL-RIP1-RIP3 necrosome complex from interacting with its downstream effectors. MLKL is a critical substrate of RIP3 during the induction of necrosis[1][2].

O=C(/C=C/C1=CC=C(S1)[N+]([O-])=O)NC2=CC=C(C=C2)S(=O)(NC3=NC=CN=C3OC)=O

-20°C,2°C to 8°C

12352200