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ProductsBack/(E/Z)-Rigosertib sodium [1225497-78-8]
(E/Z)-Rigosertib sodium [1225497-78-8]

(E/Z)-Rigosertib sodium [1225497-78-8]

T6070
TargetMol Chemicals
CAS Number1225497-78-8
DownloadMSDS
Product group Chemicals
Estimated Purity99.11%
Molecular Weight473.47
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    (E/Z)-Rigosertib sodium [1225497-78-8]
  • Delivery Days Customer
    4
  • CAS Number
    1225497-78-8
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    (E/Z)-Rigosertib sodium
  • Estimated Purity
    99.11%
  • Molecular Formula
    C21H24NNaO8S
  • Molecular Weight
    473.47
  • Scientific Description
    ON-01910 is a non-ATP-competitive PLK1 inhibitor(IC50 of 9 nM, in a cell-free assay). It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells.It is a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity.
  • Shelf life instruction
    3 years
  • SMILES
    [Na+].COc1cc(OC)c(C=CS(=O)(=O)Cc2ccc(OC)c(NCC([O-])=O)c2)c(OC)c1
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • ON 01910.Na inhibits growth of diffuse large B-cell lymphoma by cytoplasmic sequestration of sumoylated C-MYB/TRAF6 complex. Dai YH et al., 2016 Sep, Transl Res
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