Factor VII (cleaved Arg212) antibody

GeneTex

Factor VII (cleaved Arg212) antibody

9

Factor VII (cleaved Arg212) antibody detects endogenous levels of fragment of activated FA7 resulting from cleavage adjacent to Arg212.

WB: 1:500~1:1000. IHC-P: 1:50~1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

Unconjugated

F7

coagulation factor VII

coagulation factor VII; coagulation factor VII (serum prothrombin conversion accelerator); eptacog alfa; FVII coagulation protein; proconvertin; SPCA

Rabbit

IgG

Coagulation factor VII

This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015]

Human

-20°C or -80°C,2°C to 8°C

12352203