Factor X (cleaved Ile235) antibody

GeneTex

Factor X (cleaved Ile235) antibody

9

Factor X (cleaved Ile235) antibody detects endogenous levels of fragment of activated FA10 resulting from cleavage adjacent to Ile235.

WB: 1:500~1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Liquid

F10

coagulation factor X

coagulation factor X; factor X; factor Xa; FX; FXA; prothrombinase; Stuart-Prower factor

Coagulation factor X

This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015]

-20°C or -80°C,2°C to 8°C

12352203