FADD antibody

GeneTex

FADD antibody

7

WB: 1:500 - 1:2000. IHC-P: 1:50 - 1:200. IP: 1:50 - 1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

Unconjugated

FADD

Fas associated via death domain

GIG3, IMD90, MORT1, FAS-associated death domain protein, Fas (TNFRSF6)-associated via death domain, Fas-associating death domain-containing protein, Fas-associating protein with death domain, growth-inhibiting gene 3 protein, mediator of receptor-induced toxicity

Rabbit

IgG

FAS-associated death domain protein

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]

Human, Mouse, Rat

-20°C or -80°C,2°C to 8°C

12352203