FADD Polyclonal Antibody

Elabscience

FADD Polyclonal Antibody

12

Western Blot, ImmunoHistoChemistry

ELISA WB IHC

Research Use Only

Polyclonal

0.5 mg/ml

Unconjugated

FADD

Fas associated via death domain

GIG3, IMD90, MORT1, FAS-associated death domain protein, Fas (TNFRSF6)-associated via death domain, Fas-associating death domain-containing protein, Fas-associating protein with death domain, growth-inhibiting gene 3 protein, mediator of receptor-induced toxicity

Rabbit

IgG

FAS-associated death domain protein

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

-20°C

41116161