FAN1 Antibody

Cusabio

FAN1 Antibody

20

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

FAN1

FANCD2 and FANCI associated nuclease 1

coiled-coil domain-containing protein MTMR15; FANCD2/FANCI-associated nuclease 1; fanconi anemia associated nuclease 1; fanconi-associated nuclease 1; hFAN1; KIAA1018; KMIN; MTMR15; myotubularin-related protein 15

Rabbit

IgG

Fanconi-associated nuclease 1

Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5-3 exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3 flap (PubMed:25430771). Also has endonuclease activity toward 5-flaps (PubMed:20603015, PubMed:20603016, PubMed:24981866).

Human

-20°C or -80°C

41116161