WB analysis of HeLa cell lysate using GTX30142 FANCD2 antibody.
WB analysis of HeLa cell lysate using GTX30142 FANCD2 antibody.
FANCD2 antibody
GTX30142
ApplicationsFlow Cytometry, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityCanine, Human, Mouse, Primate
TargetFANCD2
Overview
- SupplierGeneTex
- Product NameFANCD2 antibody
- Delivery Days Customer9
- Antibody SpecificityThis antibody is specific for FANCD2.
- Application Supplier NoteWB: 1:10000 - 1:20000. IHC-P: 2.5 - 5 microg/ml. IP: 1:10 - 1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsFlow Cytometry, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- FormulationLiquid
- Gene ID2177
- Target nameFANCD2
- Target descriptionFA complementation group D2
- Target synonymsFA4; FACD; FAD; FAD2; FA-D2; FANCD; Fanconi anemia complementation group D2; Fanconi anemia group D2 protein
- HostRabbit
- IsotypeIgG
- Protein IDQ9BXW9
- Protein NameFanconi anemia group D2 protein
- Scientific DescriptionThe Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq]
- ReactivityCanine, Human, Mouse, Primate
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- The identification of FANCD2 DNA binding domains reveals nuclear localization sequences. Niraj J et al., 2017 Aug 21, Nucleic Acids ResRead more
- Genomically Incorporated 5-Fluorouracil that Escapes UNG-Initiated Base Excision Repair Blocks DNA Replication and Activates Homologous Recombination. Huehls AM et al., 2016 Jan, Mol PharmacolRead more
- Homologous recombination is a primary pathway to repair DNA double-strand breaks generated during DNA rereplication. Truong LN et al., 2014 Oct 17, J Biol ChemRead more
- The BRCA1-interacting protein Abraxas is required for genomic stability and tumor suppression. Castillo A et al., 2014 Aug 7, Cell RepRead more
- Diagnosis of Fanconi anemia in children with atypical clinical features: a primary study. Liu R et al., 2013 Dec, Chin Med J (Engl)Read more
- RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network. Geng L et al., 2010 Oct 18, J Cell BiolRead more
- Multiple DNA damage signaling and repair pathways deregulated by simian virus 40 large T antigen. Boichuk S et al., 2010 Aug, J VirolRead more
- Differential roles for DNA polymerases eta, zeta, and REV1 in lesion bypass of intrastrand versus interstrand DNA cross-links. Hicks JK et al., 2010 Mar, Mol Cell BiolRead more
- Cisplatin-induced DNA damage activates replication checkpoint signaling components that differentially affect tumor cell survival. Wagner JM et al., 2009 Jul, Mol PharmacolRead more
- HPV-16 E7 reveals a link between DNA replication stress, fanconi anemia D2 protein, and alternative lengthening of telomere-associated promyelocytic leukemia bodies. Spardy N et al., 2008 Dec 1, Cancer ResRead more