Farudodstat

MedChem Express

Farudodstat [1035688-66-4]

10

1035688-66-4

Research Use Only

99.95

C19H14F2N2O3

356.32

Farudodstat (ASLAN003) is an orally active and potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC 50 of 35 nM for human DHODH enzyme. Farudodstat inhibits protein synthesis via activation of AP-1 transcription factors. Farudodstat induces apoptosis and substantially prolongs survival in acute myeloid leukemia (AML) xenograft mice [1] [2] .

O=C(C1=CC=CN=C1NC2=C(F)C=C(C3=CC=CC(OC)=C3)C=C2F)O

-20°C,2°C to 8°C

12352200