Fas antibody [DX2]

GeneTex

Fas antibody [DX2]

9

Reacts specifically with the functional epitope of human Fas (CD95/Apo-1) antigen. By immunoblotting, the clone recognizes denatured, non-reduced recombinant human Fas (amino acid residues 1-173). The antibody is reactive in flow cytometry, and may be rea

FACS: 4-20 microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Flow Cytometry

Research Use Only

Monoclonal

DX2

Unconjugated

FAS

Fas cell surface death receptor

ALPS1A; APO-1; APO-1 cell surface antigen; apoptosis antigen 1; apoptosis signaling receptor FAS; apoptosis-mediating surface antigen FAS; APT1; CD95; CD95 antigen; Fas (TNF receptor superfamily, member 6); Fas AMA; FAS1; FASLG receptor; FASTM; mutant tumor necrosis receptor superfamily member 6; TNF receptor superfamily member 6; TNFRSF6; tumor necrosis factor receptor superfamily member 6; tumor necrosis factor receptor superfamily, member 6

Mouse

IgG1

Tumor necrosis factor receptor superfamily member 6

Many cells can be activated to undergo apoptosis following the interaction of selected ligands with cell surface receptors. One of the most studied receptors include the Fas receptor. Apoptosis mediated by both signaling cascades results in activation of a family of cystein proteases known as caspases. Engagement of Fas by its ligand, or by an appropriate antibody, results in the rapid induction of programmed cell death in susceptible cell lines. This process bypasses the usual long sequence of signaling enzymes and immediately activates preexisting caspases.

Human

-20°C or -80°C,2°C to 8°C

12352203