Fas/CD95, Mouse (HEK293, Fc)

MedChem Express

Fas/CD95, Mouse (HEK293, Fc)

10

Research Use Only

95.0

Fas

Fas cell surface death receptor

APO1, APT1, CD95, TNFR6, Tnfrsf6, lpr, tumor necrosis factor receptor superfamily member 6, FASLG receptor, Fas (TNF receptor superfamily member 6), Fas (TNF receptor superfamily member), Fas antigen, apo-1 antigen, apoptosis-mediating surface antigen FAS, lymphoproliferation

Tumor necrosis factor receptor superfamily member 6

Fas receptor is a cell surface death receptor, can bind to Fas ligand to form death-inducing signaling complexes, such as Fas associated death domain proteins (FADD)[1][2]. Fas receptor participates in the caspase cascade and regulate the activation of JNK and p38-K downstream. It is also involved in the signaling cascade of ERK/JNK MAPKs, activating MAPK3/ERK1, MAPK8/JNK and NF-kappaB, which has been implicated in the pathogenesis of various malignant tumors and immune system diseases[3][4]. Mouse Fas receptor contain a death domain (222-306 a.a.) that plays a key role in regulating programmed death. Fas/CD95 Protein, Mouse (HEK293, Fc) has a full length of 148 amino acids (Q22-R169), produced in HEK293 cells with C-terminal hFc-tag.

-20°C

41116100