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Fasudil (hydrochloride semihydrate)

HY-10341B
MedChem Express
CAS Number186694-02-0
Product group Chemicals
Molecular Weight673.68
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Fasudil (hydrochloride semihydrate)
  • Delivery Days Customer
    10
  • CAS Number
    186694-02-0
  • Certification
    Research Use Only
  • Molecular Formula
    C14H17N3O2S.ClH.1/2H2O
  • Molecular Weight
    673.68
  • Scientific Description
    Fasudil (HA-1077; AT877) hydrochloride semihydrate is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 microM for ROCK1, IC50s of 0.158 microM and 4.58 microM, 12.30 microM, 1.650 microM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil hydrochloride semihydrate is also a potent Ca2+ channel antagonist and vasodilator[1][2][3].
  • SMILES
    O=S(C1=CC=CC2=C1C=CN=C2)(N3CCNCCC3)=O.[H]Cl.[0.5H2O]
  • UNSPSC
    12352200