FAT4 Antibody

Cusabio

FAT4 Antibody

20

ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

Rabbit

IgG

FAT1, FAT2, FAT3 and FAT4 are human homologs of Drosophila Fat, which is involved in tumor suppression and planar cell polarity (PCP). FAT4 undergo the first proteolytic cleavage by Furin and are predicted to undergo the second cleavage by gamma secretase to release intracellular domain (ICD). FAT4 directly interacts with MPDZ/MUPP1 to recruit membrane associated guanylate kinase MPP5/PALS1. FAT4 is involved in the maintenance of PCP and inhibition of cell proliferation.

Human

-20°C or -80°C

12352203