ProductsBack/FBXO9 Antibody

Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA891719LA01HU at dilution of 1:100

FBXO9 Antibody

Name: FBXO9 Antibody
SKU: CSB-PA891719LA01HU_C90
Availability: BackOrder

CSB-PA891719LA01HU

ApplicationsImmunoFluorescence, ELISA, ImmunoHistoChemistry

Product group Antibodies

ReactivityHuman

TargetFBXO9

Overview

Supplier
Cusabio
Product Name
FBXO9 Antibody
Delivery Days Customer
20
Applications
ImmunoFluorescence, ELISA, ImmunoHistoChemistry
Certification
Research Use Only
Clonality
Polyclonal
Conjugate
Unconjugated
Gene ID26268
Target name
FBXO9
Target description
F-box protein 9
Target synonyms
FBX9, NY-REN-57, VCIA1, dJ341E18.2, F-box only protein 9, F-box protein Fbx9, cross-immune reaction antigen 1, renal carcinoma antigen NY-REN-57
Host
Rabbit
Isotype
IgG
Protein IDQ9UK97
Protein Name
F-box only protein 9
Scientific Description
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1.
Reactivity
Human
Storage Instruction
-20°C or -80°C
UNSPSC
41116161