Western blot All lanes: FBXW5 antibody at 2ug/ml + PC-3 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 64, 43 kDa Observed band size: 64 kDa

FBXW5 Antibody

CSB-PA846577LA01HU

ApplicationsImmunoFluorescence, Western Blot, ELISA, ImmunoHistoChemistry

Product group Antibodies

ReactivityHuman

TargetFBXW5

Overview

Supplier
Cusabio
Product Name
FBXW5 Antibody
Delivery Days Customer
20
Applications
ImmunoFluorescence, Western Blot, ELISA, ImmunoHistoChemistry
Certification
Research Use Only
Clonality
Polyclonal
Conjugate
Unconjugated
Gene ID54461
Target name
FBXW5
Target description
F-box and WD repeat domain containing 5
Target synonyms
F-box and WD-40 domain-containing protein 5; F-box/WD repeat-containing protein 5; Fbw5; WD repeat-containing F-box protein FBW5
Host
Rabbit
Isotype
IgG
Protein IDQ969U6
Protein Name
F-box/WD repeat-containing protein 5
Scientific Description
Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway.
Reactivity
Human
Storage Instruction
-20°C or -80°C
UNSPSC
12352203

FBXW5 Antibody

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Overview