FcRn (FCGRT/B2M) Blocker (Efgartigimod)

BPS Bioscience

FcRn (FCGRT/B2M) Blocker (Efgartigimod)

7

Research Use Only

≥90%

51.2 kDa (homo-dimer); Chain: 25.6 kDa

The FcRn (FCGRT/B2M) Blocker (Efgartigimod) is a recombinant human protein corresponding to the Fc region of an antibody which has been engineered to bind to the human neonatal Fc Receptor of IgG (FcRn; FCGRT/B2M) with high affinity. This protein has been tested for specific binding to human FcRn (BPS Bioscience #71283) and it blocks the binding of FcRn to IgG. The FcRn blocker is comparable to Efgartigimod alfa-fcab. It contains 5 mutations, M252Y, S254T, T256E, H433K, N434F, that increase its potency by increasing its affinity towards FcRn at low pH. This protein was affinity purified.

-80°C

12161509