FD223 [2050524-24-6]

TargetMol Chemicals

FD223 [2050524-24-6]

72

2050524-24-6

Research Use Only

FD223

C17H12ClN5O2S

385.83

FD223 is a potent, selective phosphoinositide 3-kinase delta (PI3Kdelta) inhibitor with a marked affinity (IC50=1 nM), demonstrating notable selectivity against other isoforms (IC50s: alpha=51 nM, beta=29 nM, gamma=37 nM). This compound effectively suppresses the proliferation of acute myeloid leukemia (AML) cell lines by inhibiting p-AKT Ser473, thereby inducing G1 phase cell cycle arrest. FD223 holds promise for leukemia research, particularly in AML[1].

3 years

Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1cnc2[nH]ncc2c1

-20°C

12352200