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Fedratinib (hydrochloride hydrate)

HY-10409A
MedChem Express
CAS Number1374744-69-0
Product group Chemicals
Estimated Purity99.92
Molecular Weight615.62
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Fedratinib (hydrochloride hydrate) [1374744-69-0]
  • Delivery Days Customer
    9
  • CAS Number
    1374744-69-0
  • Certification
    Research Use Only
  • Estimated Purity
    99.92
  • Molecular Formula
    C27H40Cl2N6O4S
  • Molecular Weight
    615.62
  • Scientific Description
    Fedratinib hydrochloride hydrate (TG-101348 hydrochloride hydrate) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor with IC 50 s of 3 nM for both JAK2 and JAK2V617F kinase . Fedratinib hydrochloride hydrate shows 35- and 334-fold selectivity over JAK1 and JAK3, respectively. Fedratinib hydrochloride hydrate induces cancer cell apoptosis and has the potential for myeloproliferative disorders research [1] [2] .
  • SMILES
    [H]Cl.[H]O[H].[H]Cl.O=S(C1=CC=CC(NC2=NC(NC3=CC=C(C=C3)OCCN4CCCC4)=NC=C2C)=C1)(NC(C)(C)C)=O
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200

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