FEN1-IN-1 [824983-91-7]
HY-123834
Overview
- SupplierMedChem Express
- Product NameFEN1-IN-1 [824983-91-7]
- Delivery Days Customer10
- CAS Number824983-91-7
- CertificationResearch Use Only
- Estimated Purity99.50
- Molecular FormulaC15H12N2O5S
- Molecular Weight332.33
- Scientific DescriptionFEN1-IN-1 (compound 1) is a small molecule flap endonuclease 1 (FEN1) inhibitor with antitumor activity. FEN1-IN-1 binds to the active site of FEN1 and partly achieves inhibition by the co-ordination of Mg2+ ions. FEN1-IN-1 initiaties a DNA damage response and activates the ATM checkpoint signalling pathway, the phosphorylation of histone H2AX and the ubiquitination of FANCD2 in mammalian cells. FEN1-IN-1 is promising for research of cancers[1].
- SMILESO=C1N(CC2OC3=CC=CC=C3OC2)C(C=CS4)=C4C(N1O)=O
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200