Fenebrutinib

MedChem Express

Fenebrutinib [1434048-34-6]

10

1434048-34-6

Research Use Only

99.42

C37H44N8O4

664.80

Fenebrutinib (GDC-0853) is a potent, selective, orally available, and noncovalent brutons tyrosine kinase ( Btk ) inhibitor with K i s of 0.91 nM, 1.6, 1.3, 12.6, and 3.4 nM for WT Btk, and the C481S, C481R, T474I, T474M mutants. Fenebrutinib has the potential for rheumatoid arthritis and systemic lupus erythematosus research [1] .

O=C1C(NC(C=C2)=NC=C2N3CCN(C4COC4)C[C@@H]3C)=CC(C5=CC=NC(N6C(C7=CC(CC(C)(C)C8)=C8N7CC6)=O)=C5CO)=CN1C

2°C to 8°C

12352200