Fenebrutinib

MedChem Express

Fenebrutinib [1434048-34-6]

10

1434048-34-6

Research Use Only

99.42

C37H44N8O4

664.80

Fenebrutinib (GDC-0853) is a potent, selective, orally available, and noncovalent brutons tyrosine kinase (Btk) inhibitor with Kis of 0.91 nM, 1.6, 1.3, 12.6, and 3.4 nM for WT Btk, and the C481S, C481R, T474I, T474M mutants. Fenebrutinib has the potential for rheumatoid arthritis and systemic lupus erythematosus research[1].

O=C1C(NC(C=C2)=NC=C2N3CCN(C4COC4)C[C@@H]3C)=CC(C5=CC=NC(N6C(C7=CC(CC(C)(C)C8)=C8N7CC6)=O)=C5CO)=CN1C

2°C to 8°C

12352200