FGFR-IN-10

MedChem Express

FGFR-IN-10 [2847092-41-3]

10

Research Use Only

C28H30FN9O2

543.60

FGFR-IN-10 is an orally active inhibitor of FGFR and Cytochrome P450 (CYPs). FGFR-IN-10 inhibits wide type and V564F mutant FGFR2 with IC50s of 104.1 nM and 43.6 nM, respectively. FGFR-IN-10 also inhibits CYPs with IC50s of 3.33 microM (CYP2C9), 18.75 microM (CYP2C19), 4.34 microM (CYP2CD6), and 0.69 microM (CYP3A4), respectively[1].

FC(C=C1C2=CN=C(N=C2N3C[C@H](N([C@@H](C3)C)C(C=C)=O)C)NC4=CN(N=C4)C)=C(C=C1)OC5=NC=CC(C)=N5

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