Fimaporfin

Biorbyt

Fimaporfin

10

1443547-43-0

Research Use Only

98.00%

C44H32N4O6S2

776.88

Fimaporfin, also known as TPCS2a, is a potent chlorin-based photosensitizer, Fimaporfin is consisted of a mixture of three isomers A, B and C (25%,50%,25%). Fimaporfin has been developed by di-imide reduction of disulfonated tetraphenyl porphine (TPPS(2a)). The synthesized TPCS(2a) contains 3 isomers as shown by HPLC with low (<4%) inter-batch variation with respect to isomer formation, less than 0.5% (w/w) of the starting material TPPS(2a) and absorbs light at 652 nm. TPCS(2a) was found to be a clinically suitable PCI photosensitizer for photochemical activation of molecules that do not readily penetrate the cellular plasma membrane.

O=S(C(C=C1)=CC=C1C2=C(N3)C=CC3=C(C4=CC=CC=C4)C5=NC(C=C5)=C(C6=CC=CC=C6)C(N7)=CC=C7C(C8=CC=C(S(=O)(O)=O)C=C8)=C9N=C2CC9)(O)=O

-20°C

12352200