FK-506-13C,D2 (Major) (Tacrolimus) (>85%) [1356841-89-8]

Toronto Research Chemicals

FK-506-13C,D2 (Major) (Tacrolimus) (>85%) [1356841-89-8]

15

1356841-89-8

Research Use Only

yes

13C C43 D2 H67 N O12

807.02

A labelled immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release. A representative lot contained a distribution of 20% d-1, 40% d-2 and 20% d-3.

45844

[2H][13C](=CC[C@@H]1\C=C(/C)\C[C@H](C)C[C@H](OC)[C@H]2O[C@](O)([C@H](C)C[C@@H]2OC)C(=O)C(=O)N3CCC[C@H](C3)C(=O)O[C@@H]([C@H](C)[C@@H](O)CC1=O)\C(=C\[C@@H]4CC[C@@H](O)[C@@H](C4)OC)\C)[2H]

-20°C

12352200