FK888

MedChem Express

FK888 [138449-07-7]

10

138449-07-7

Research Use Only

C36H36N4O4

588.70

FK888 is a potent, selective, and high affinity dipeptide NK1 receptor antagonist. FK888 displaces [3H]-SP binding with a K i value of 0.69 nM and 0.45 microM. FK888 also inhibits SP-induced airway oedema in guinea-pig after both intravenous and oral administration [1] .

O=C(N(C[C@@H]1O)[C@@H](C1)C(N[C@H](C(N(C)CC2=CC=CC=C2)=O)CC3=CC(C=CC=C4)=C4C=C3)=O)C(C5=CC=CC=C56)=CN6C

12352200