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FL118 [135415-73-5]

FL118 [135415-73-5]

T77701
TargetMol Chemicals
Estimated Purity98.99%
DownloadMSDS
Product group Chemicals
Molecular Weight392.36
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    FL118 [135415-73-5]
  • Delivery Days Customer
    9
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    FL118
  • Estimated Purity
    98.99%
  • Molecular Formula
    C21H16N2O6
  • Molecular Weight
    392.36
  • Scientific Description
    FL118 is a novel survivin inhibitor that inhibits cancer stem cell-like properties.FL118 is a novel camptothecin analog with anticancer activity that inhibits epithelial-mesenchymal transition through the Wnt/beta-catenin signaling pathway, thereby inhibiting migration and invasion of human breast cancer cells.
  • Shelf life instruction
    3 years
  • SMILES
    C(C)[C@]1(O)C2=C(C(=O)N3C(=C2)C=4C(C3)=CC=5C(N4)=CC6=C(C5)OCO6)COC1=O
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • FL118, acting as a molecular glue degrader, binds to dephosphorylates and degrades the oncoprotein DDX5 (p68) to control c-Myc, survivin and mutant Kras against colorectal and pancreatic cancer with high efficacy. Ling X et al., 2022 May, Clin Transl Med
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