FL118 [135415-73-5]
T77701
Estimated Purity98.99%
Product group Chemicals
Molecular Weight392.36
Overview
- SupplierTargetMol Chemicals
- Product NameFL118 [135415-73-5]
- Delivery Days Customer9
- CertificationResearch Use Only
- Chemical NameFL118
- Estimated Purity98.99%
- Molecular FormulaC21H16N2O6
- Molecular Weight392.36
- Scientific DescriptionFL118 is a novel survivin inhibitor that inhibits cancer stem cell-like properties.FL118 is a novel camptothecin analog with anticancer activity that inhibits epithelial-mesenchymal transition through the Wnt/beta-catenin signaling pathway, thereby inhibiting migration and invasion of human breast cancer cells.
- Shelf life instruction3 years
- SMILESC(C)[C@]1(O)C2=C(C(=O)N3C(=C2)C=4C(C3)=CC=5C(N4)=CC6=C(C5)OCO6)COC1=O
- Storage Instruction-20°C
- UNSPSC12352200
References
- Ling X, Wu W, Aljahdali IAM, et al. FL118, acting as a 'molecular glue degrader', binds to dephosphorylates and degrades the oncoprotein DDX5 (p68) to control c-Myc, survivin and mutant Kras against colorectal and pancreatic cancer with high efficacy. Clin Transl Med. 2022,12(5):e881. doi: 10.1002/ctm2.881Read this paper
MSDS
Related products
Product group Chemicals
FL118 [135415-73-5]HY-12486
CAS Number135415-73-5
Estimated Purity99.40
Molecular Weight392.36
- SizePrice
