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Flavopiridol (Alvocidib) HCl

S2679
Selleck Chemicals
Estimated Purity...
Product group Chemicals
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Overview

  • Supplier
    Selleck Chemicals
  • Product Name
    Flavopiridol (L86-8275) HCl [131740-09-5]
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Estimated Purity
    ...
  • Scientific Description
    Flavopiridol (Alvocidib) HCl competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM in cell-free assays. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol HCl induces autophagy and ER stress. Flavopiridol HCl blocks HIV-1 replication. Phase 1/2.
  • Storage Instruction
    -80°C
  • UNSPSC
    12352200

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