FLT3/TrKA-IN-1

MedChem Express

FLT3/TrKA-IN-1

10

Research Use Only

C28H30N4O2

454.56

FLT3/TrKA-IN-1 is a potent FLT3/TrKA dual kinase inhibitor with the IC50s of 43.8 nM, 97.2 nM, 92.5 nM and 23.6 nM for FLT3, FLT3-ITD, FLT3-TKD and TrKA, respectively. FLT3/TrKA-IN-1 induces cell cycle arrest at the G0/G1 phase as well as apoptosis and shows antiproliferative activity in vitro. FLT3/TrKA-IN-1 has the potential for the research of Acute myeloid leukemia (AML).

CC(NC1=CC=C(C=C1)N2C=NC3=CC(C4=CC=C(C=C4)OCCN5CCCCC5)=CC=C32)=O

See Manual

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