Fludarabine triphosphate [74832-57-8]
HY-136650
CAS Number74832-57-8
Product group Chemicals
Molecular Weight525.17
Overview
- SupplierMedChem Express
- Product NameFludarabine triphosphate [74832-57-8]
- Delivery Days Customer10
- CAS Number74832-57-8
- CertificationResearch Use Only
- Molecular FormulaC10H15FN5O13P3
- Molecular Weight525.17
- Scientific DescriptionFludarabine triphosphate (F-ara-ATP), the active metabolite of Fludarabine (HY-B0069), is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC50 of 2.3 microM and a Ki of 6.1 microM. Fludarabine triphosphate inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis[1][2].
- SMILESO[C@@H]([C@@H]1O)[C@](O[C@@H]1CO[P](O[P](O[P](O)(O)=O)(O)=O)(O)=O)([H])N2C3=NC(F)=NC(N)=C3N=C2
- UNSPSC12352200
MSDS
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CAS Number74832-57-8
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