Fmoc-L-Asn(EDA-N3)-OH

MedChem Express

Fmoc-L-Asn(EDA-N3)-OH [2616562-74-2]

10

Research Use Only

C21H21N5O5

423.42

Fmoc-L-Asn(EDA-N3)-OH is a click chemistry reagent containing an azide group. This building block is reported in literature for the modification of Amanitin via Click Chemistry. Alpha-Amanitin is the deadliest member of the amatoxin peptide family produced by the death-cap mushroom A. phalloides. It is an orally available, rigid, bicyclic octapeptide and one of the most lethal known natural products (LD50 = 50-100 microg/kg) acting as highly selective allosteric inhibitor of the RNA polymerase II[1]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

[N-]=[N+]=NCCNC(C[C@@H](C(O)=O)NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)=O

41115800