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Folate Receptor beta antibody

GTX105822
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHamster, Human, Mouse
TargetFOLR2
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Overview

  • Supplier
    GeneTex
  • Product Name
    Folate Receptor beta antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.34 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID2350
  • Target name
    FOLR2
  • Target description
    folate receptor beta
  • Target synonyms
    BETA-HFR; FBP; FBP/PL-1; folate receptor 2 (fetal); folate receptor alpha; folate receptor beta; folate receptor, fetal/placental; folate-binding protein, fetal/placental; FOLR1; FRbeta; FR-BETA; FR-P3; placental folate-binding protein
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP14207
  • Protein Name
    Folate receptor beta
  • Scientific Description
    The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
  • Reactivity
    Hamster, Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment.
    Read more
  • Identification of a PET Radiotracer for Imaging of the Folate Receptor-alpha: A Potential Tool to Select Patients for Targeted Tumor Therapy. Guzik P et al., 2021 Oct, J Nucl Med
    Read more
  • Targeted silver nanoparticles for rheumatoid arthritis therapy via macrophage apoptosis and Re-polarization. Yang Y et al., 2021 Jan, Biomaterials
    Read more
  • Nanovector Assembled from Natural Egg Yolk Lipids for Tumor-Targeted Delivery of Therapeutics. Tang Z et al., 2020 Feb 19, ACS Appl Mater Interfaces
    Read more
  • 18F-AzaFol for Detection of Folate Receptor-beta Positive Macrophages in Experimental Interstitial Lung Disease-A Proof-of-Concept Study. Schniering J et al., 2019, Front Immunol
    Read more
  • Growing Mouse Oocytes Transiently Activate Folate Transport via Folate Receptors As They Approach Full Size. Meredith M et al., 2016 Jun, Biol Reprod
    Read more