Folylpolyglutamate synthase antibody [N3C2], Internal
GTX103516
ApplicationsWestern Blot
Product group Antibodies
TargetFPGS
Overview
- SupplierGeneTex
- Product NameFolylpolyglutamate synthase antibody [N3C2], Internal
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID2356
- Target nameFPGS
- Target descriptionfolylpolyglutamate synthase
- Target synonymsfolylpolyglutamate synthase, mitochondrial, folylpoly-gamma-glutamate synthetase, tetrahydrofolate synthase, tetrahydrofolylpolyglutamate synthase
- HostRabbit
- IsotypeIgG
- Protein IDQ05932
- Protein NameFolylpolyglutamate synthase, mitochondrial
- Scientific DescriptionThis gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. While several transcript variants may exist for this gene, the full-length natures of only two have been biologically validated to date. These two variants encode distinct isoforms. [provided by RefSeq]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Kuo WT, Tu DG, Chiu LY, et al. High pemetrexed sensitivity of docetaxel-resistant A549 cells is mediated by TP53 status and downregulated thymidylate synthase. Oncol Rep. 2017,38(5):2787-2795. doi: 10.3892/or.2017.5951Read this paper
- Chiu LY, Hsin IL, Yang TY, et al. The ERK-ZEB1 pathway mediates epithelial-mesenchymal transition in pemetrexed resistant lung cancer cells with suppression by vinca alkaloids. Oncogene. 2017,36(2):242-253. doi: 10.1038/onc.2016.195Read this paper




