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Folylpolyglutamate synthase antibody [N3C2], Internal

GTX103516
GeneTex
ApplicationsWestern Blot
Product group Antibodies
TargetFPGS
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Overview

  • Supplier
    GeneTex
  • Product Name
    Folylpolyglutamate synthase antibody [N3C2], Internal
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID2356
  • Target name
    FPGS
  • Target description
    folylpolyglutamate synthase
  • Target synonyms
    folylpoly-gamma-glutamate synthetase; folylpolyglutamate synthase, mitochondrial; tetrahydrofolate synthase; tetrahydrofolylpolyglutamate synthase
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ05932
  • Protein Name
    Folylpolyglutamate synthase, mitochondrial
  • Scientific Description
    This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. While several transcript variants may exist for this gene, the full-length natures of only two have been biologically validated to date. These two variants encode distinct isoforms. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • High pemetrexed sensitivity of docetaxel-resistant A549 cells is mediated by TP53 status and downregulated thymidylate synthase. Kuo WT et al., 2017 Nov, Oncol Rep
    Read more
  • The ERK-ZEB1 pathway mediates epithelial-mesenchymal transition in pemetrexed resistant lung cancer cells with suppression by vinca alkaloids. Chiu LY et al., 2017 Jan 12, Oncogene
    Read more

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