Folylpolyglutamate synthase antibody [N3C2], Internal
GTX103516
Overview
- SupplierGeneTex
- Product NameFolylpolyglutamate synthase antibody [N3C2], Internal
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID2356
- Target nameFPGS
- Target descriptionfolylpolyglutamate synthase
- Target synonymsfolylpoly-gamma-glutamate synthetase; folylpolyglutamate synthase, mitochondrial; tetrahydrofolate synthase; tetrahydrofolylpolyglutamate synthase
- HostRabbit
- IsotypeIgG
- Protein IDQ05932
- Protein NameFolylpolyglutamate synthase, mitochondrial
- Scientific DescriptionThis gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. While several transcript variants may exist for this gene, the full-length natures of only two have been biologically validated to date. These two variants encode distinct isoforms. [provided by RefSeq]
- ReactivityHuman
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- High pemetrexed sensitivity of docetaxel-resistant A549 cells is mediated by TP53 status and downregulated thymidylate synthase. Kuo WT et al., 2017 Nov, Oncol RepRead more
- The ERK-ZEB1 pathway mediates epithelial-mesenchymal transition in pemetrexed resistant lung cancer cells with suppression by vinca alkaloids. Chiu LY et al., 2017 Jan 12, OncogeneRead more