Fonsartan (free acid) [144628-52-4]
HY-119379
CAS Number144628-52-4
Product group Chemicals
Molecular Weight544.69
Overview
- SupplierMedChem Express
- Product NameFonsartan (free acid) [144628-52-4]
- Delivery Days Customer9
- CAS Number144628-52-4
- CertificationResearch Use Only
- Molecular FormulaC26H32N4O5S2
- Molecular Weight544.69
- Scientific DescriptionFonsartan (HOE-720) free acid is an orally active angiotensin II receptor (AT1R) antagonist with an IC50 value of 0.48 nM, exhibiting potent antihypertensive activity. Fonsartan free acid dose-dependently inhibits angiotensin II-induced pressor response in rats (ID50 = 0.11 mg/kg) and shows significant long-lasting blood pressure-lowering effects in high-renin animal models. Fonsartan free acid is primarily used in research on hypertension and cardiovascular diseases[1].
- SMILESO=C(C1=C(SC)N=C(CCCC)N1CC2=CC=C(C3=C(S(=O)(NC(NCCC)=O)=O)C=CC=C3)C=C2)O
- UNSPSC12352200