Forskolin [66428-89-5]

AdipoGen Life Sciences

Forskolin

10

66428-89-5

Research Use Only

>99%

Warning

C22H34O7

410.5

Chemical. CAS: 66428-89-5 and 66575-29-9. Formula: C22H34O7. MW: 410.5. Isolated from Coleus forskohlii. Potent, cell permeable adenylyl cyclase activator. Increases intracellular cAMP levels. Widely used tool to investigate cAMP as a second messenger. Inotropic and antihypertensive. Smooth muscle relaxant/vasodilator. Glucose transporter inhibitor. Platelet aggregation inhibitor. Stimulates lipolysis in fat cells. Non-competitive nicotinic acetylcholine receptors inhibitor. MAP kinase inhibitor. Upregulates mitochondrial uncoupling protein (UCP) mRNA levels in brown adipose tissue. Autophagy inhibitor. Hedgehog signaling inhibitor. Has antiglaucoma potential. Promotes neuronal differentiation of NSCs. - Potent, cell permeable adenylyl cyclase activator. Increases intracellular cAMP levels [1, 2, 6]. Widely used tool to investigate cAMP as a second messenger [15]. Inotropic and antihypertensive. Smooth muscle relaxant/vasodilator [3, 4, 6]. Glucose transporter inhibitor [4]. Platelet aggregation inhibitor [3, 10]. Stimulates lipolysis in fat cells [8]. Non-competitive nicotinic acetylcholine receptors inhibitor [9]. MAP kinase inhibitor [11]. Upregulates mitochondrial uncoupling protein (UCP) mRNA levels in brown adipose tissue [12]. Autophagy inhibitor [13]. Hedgehog signaling inhibitor [14]. Has antiglaucoma potential [16]. Promotes neuronal differentiation of NSCs [17]. Anti-neuroinflammatory and neuroprotective agent. Ameliorated Alzheimers disease symptoms, restoring impairment in nesting ability and sociability, and reducing neuroinflammation and amyloid beta deposition [18].

[H][C@@]12[C@H](O)[C@H](OC(C)=O)[C@@]3(C)O[C@](C)(CC(=O)[C@]3(O)[C@@]1(C)[C@@H](O)CCC2(C)C)C=C

-20°C,2°C to 8°C

12352200