Fostamatinib (disodium hexahydrate) [914295-16-2]

MedChem Express

Fostamatinib (disodium hexahydrate) [914295-16-2]

9

914295-16-2

Research Use Only

99.51

C23H36FN6Na2O15P

732.51

Fostamatinib (R788) disodium hexahydrate is the oral proagent of the active compound R406[1]. R406 is an orally available and competitive Syk/FLT3 inhibitor with a Ki of 30 nM and an IC50 of 41 nM[2]. R406 also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM)[3].

COC1=CC(NC2=NC=C(C(NC3=NC(N4COP(O[Na])(O[Na])=O)=C(C=C3)OC(C)(C)C4=O)=N2)F)=CC(OC)=C1OC.O.O.O.O.O.O

2°C to 8°C

12352200