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Immunohistochemistry analysis of paraffin-embedded human lung cancer using FOXO1 Polyclonal Antibody at dilution of 1:300.
Immunohistochemistry analysis of paraffin-embedded human lung cancer using FOXO1 Polyclonal Antibody at dilution of 1:300.
Immunohistochemistry analysis of paraffin-embedded human lung cancer using FOXO1 Polyclonal Antibody at dilution of 1:300.

FOXO1 Polyclonal Antibody

Research Use Only
E-AB-70144
Elabscience
Product group Antibodies
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Overview

  • Supplier
    Elabscience
  • Product Name
    FOXO1 Polyclonal Antibody
  • Delivery Days Customer
    12
  • Certification
    Research Use Only
  • Scientific Description
    FOXO1,also named as FOXO1A,FKHR and FKH1,is a member of the FOXO subfamily of Forkhead transcription factors. FOXO1 is a transcription factor which acts as a regulator of cell responses to oxidative stress. FOXO1 interacts with LRPPRC and SIRT1. In the presence of KIRT1,FOXO1 mediates down-regulation of cyclin D1 and up-regulation of CDKN1B levels which are required for cell transition from proliferative growth to quiescence. FOXO1 contains three predicted protein kinase B phosphorylation sites (Thr-24,Ser-256,and Ser-319) that are conserved in other FOXO proteins. The t(2;13) and the variant t(1;13) translocations generate PAX3/FKHR and PAX7/FKHR fusion proteins respectively. The resulting protein is a transcriptional activator. Defects in FOXO1 are a cause of rhabdomyosarcoma type 2 (RMS2).
  • UNSPSC
    12352203