FPH1 --- Hepatocytes Functional Proliferation Inducer [708219-39-0] [708219-39-0]
BS-60126C
CategoryCell Culture Media Reagents
Product group Cell Culture
Overview
- SupplierBioss
- Product NameFPH1 --- Hepatocytes Functional Proliferation Inducer [708219-39-0] [708219-39-0]
- Delivery Days Customer16
- CAS Number708219-39-0
- CertificationResearch Use Only
- ConjugateUnconjugated
- Estimated Purity98 - 98.0
- Molecular FormulaC16 H15 Cl F2 N2 O3 S
- Molecular Weight388.82
- Scientific DescriptionFPH1 is a potent and selective small molecule that induced Functional Proliferation of primary human Hepatocytes in vitro, identified by a high-throughput, cell-based screening using primary human hepatocytes. It induced a significant increase in hepatocyte number and elevated the number of hepatocytes undergoing mitosis in a dose-dependent manner. Cells treated with FPH1 also maintained their liver-specific functions. Immunofluorescence staining for Ki67 and albumin, along with FACS-based cell counting, revealed that hepatocytes from a wide range of genetically diverse individuals could be expanded and normal hepatocytes functions could be maintained after expansion. FPH1 can also promote the differentiation of iPS cells toward a hepatic lineage and promote the maturation of induced hepatic cells toward a more adult-like liver phenotype.
- SMILESCC1C=CC(Cl)=CC=1N(CC(=O)NC1C(F)=CC=CC=1F)S(C)(=O)=O
- Storage Instruction-20°C
- UNSPSC41106200