WB analysis of various sample lysates using GTX54036 Frataxin antibody. Dilution : 1:1000 Loading : 25microg per lane
WB analysis of various sample lysates using GTX54036 Frataxin antibody. Dilution : 1:1000 Loading : 25microg per lane
Frataxin antibody
GTX54036
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetFXN
Overview
- SupplierGeneTex
- Product NameFrataxin antibody
- Delivery Days Customer7
- Application Supplier NoteWB: 1:500 - 1:2000. ICC/IF: 1:50 - 1:200. IHC-P: 1:50 - 1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID2395
- Target nameFXN
- Target descriptionfrataxin
- Target synonymsCyaY, FA, FARR, FRDA, X25, frataxin, mitochondrial, Friedreich ataxia protein
- HostRabbit
- IsotypeIgG
- Protein IDQ16595
- Protein NameFrataxin, mitochondrial
- Scientific DescriptionThis nuclear gene encodes a mitochondrial protein which belongs to the FRATAXIN family. The protein functions in regulating mitochondrial iron transport and respiration. The expansion of intronic trinucleotide repeat GAA from 8-33 repeats to >90 repeats results in Friedreich ataxia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Napierala JS, Rajapakshe K, Clark A, et al. Reverse Phase Protein Array Reveals Correlation of Retinoic Acid Metabolism With Cardiomyopathy in Friedreich's Ataxia. Mol Cell Proteomics. 2021,20:100094. doi: 10.1016/j.mcpro.2021.100094Read this paper
- Fil D, Chacko BK, Conley R, et al. Mitochondrial damage and senescence phenotype of cells derived from a novel frataxin G127V point mutation mouse model of Friedreich's ataxia. Dis Model Mech. 2020,13(7). doi: 10.1242/dmm.045229Read this paper
- Li J, Li Y, Wang J, et al. Defining Transcription Regulatory Elements in the Human Frataxin Gene: Implications for Gene Therapy. Hum Gene Ther. 2020,31(15-16):839-851. doi: 10.1089/hum.2020.053Read this paper
- Zhao H, Lewellen BM, Wilson RJ, et al. Long-term voluntary running prevents the onset of symptomatic Friedreich's ataxia in mice. Sci Rep. 2020,10(1):6095. doi: 10.1038/s41598-020-62952-6Read this paper
- Ast T, Meisel JD, Patra S, et al. Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis. Cell. 2019,177(6):1507-1521.e16. doi: 10.1016/j.cell.2019.03.045Read this paper
Datasheet
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