Full Length Notch1/CSL Luciferase Reporter HEK293 Cell Line

BPS Bioscience

Full Length Notch1/CSL Luciferase Reporter HEK293 Cell Line

7

Research Use Only

The Full Length Notch1/CSL Luciferase Reporter HEK293 Cell Line is a HEK293 cell line that expresses the firefly luciferase reporter under the control of Notch-response elements (CSL responsive elements) and full-length Notch1 (accession number: NM_017617.5). Upon ligand-receptor interaction, the Notch1 receptor is cleaved by gamma-secretase. This active Notch1 NICD (Notch intracellular domain) translocate to the nucleus and induces the expression of the luciferase reporter. The cell line was functionally validated for both activation and inhibition of the expression of luciferase reporter with DAPT and DLL4

Liquid Nitrogen

41116155