Funalenone [259728-61-5]

TargetMol Chemicals

Funalenone [259728-61-5]

44

259728-61-5

Chemical

Research Use Only

Funalenone

C15H12O6

288.255

Funalenone is a phenalenone originally isolated from A. niger. It inhibits HIV-1 integrase (IC50 = 10 microM) and HIV-1 replication in human peripheral blood cells transformed by murine leukemia virus (HPB-M(a); IC50 = 1.7 microM) but is less cytotoxic to mammalian HPB-M(a) cells (IC50 = 87 microM). Funalenone selectively inhibits matrix metalloproteinase-1 (MMP-1; IC50 = 170 microM) over MMP-2 and MMP-9, which it inhibits by 18.3 and 38.2%, respectively, when used at a concentration of 400 microM. It also inhibits the bacterial cell wall synthesis enzymes MraY and MurG (IC50s = 25.5 microM in a membrane plate assay) and inhibits growth of S. aureus with a MIC value of 64 microg/mL.

3 years

COC1=C(O)c2c(O)cc(C)c3c(O)cc(O)c(C1=O)c23 - c:2 -

-20°C

12352200