Fuscin [83-85-2]

TargetMol Chemicals

Fuscin [83-85-2]

16

83-85-2

Chemical

Research Use Only

Fuscin

C15H16O5

276.288

Fuscin is a quinonoid fungal metabolite originally isolated from O. fuscum that has diverse biological activities. It inhibits binding of the ADP/ATP translocase inhibitor atractyloside to rat liver mitochondria in an ADP-dependent manner when used at a concentration of 50 microM in a radioligand binding assay. Fuscin (20 microM) reduces the glutathione content of rat liver mitochondria to 28% of controls and inhibits NADH oxidation in sonicated pigeon heart mitochondria preparations in a concentration-dependent manner. It competes with macrophage inflammatory protein 1alpha (MIP-1alpha) for binding to CCR5 chemokine receptors in vitro with an IC50 value of 21 microM.

3 years

CC1OC(=O)C=C2C3=C(OC(C)(C)CC3)C(=O)C(O)=C12 - t:5,7,19 -

-20°C

12352200