FXR agonist 4

MedChem Express

FXR agonist 4 [3025841-47-5]

10

Research Use Only

C21H28ClN3O

373.92

FXR agonist 4 (compound 10a) is an agonist of farnesoid X receptor (FXR) with an EC50 value of 1.05 microM. FXR agonist 4 effectively improves hyperlipidemia, hepatic steatosis, insulin resistance and hepatic inflammation in DIO mice. FXR agonist 4 can be used for the research of non-alcoholic fatty liver disease (NAFLD)[1].

ClC1=CC(N2CCN(C(C34C[C@@H]5C[C@H](C4)C[C@@H](C5)C3)=O)CC2)=C(N)C=C1

12131703