FzM1.8 [2204290-85-5]
HY-117163
CAS Number2204290-85-5
Product group Chemicals
Estimated Purity98.93
Molecular Weight322.31
Overview
- SupplierMedChem Express
- Product NameFzM1.8 [2204290-85-5]
- Delivery Days Customer5
- CAS Number2204290-85-5
- CertificationResearch Use Only
- Estimated Purity98.93
- Molecular FormulaC18H14N2O4
- Molecular Weight322.31
- Scientific DescriptionFzM1.8, derives from FzM1, is an allosteric agonist of FZD4 with pEC50 of 6.4. FzM1.8 binds to FZD4 and activates the WNT/beta-catenin pathway, by promoting TCF/LEF transcriptional activity in the absence of any WNT ligand. FzM1.8 stabilizes FZD4 with an increased affinity for heterotrimeric G protein and stimulates the release of the Gbetagamma subunit that in turn activates PI3K[1].
- SMILESO=C(O)C1=CC(NC(NC2=CC=C3C=CC=CC3=C2)=O)=CC(O)=C1
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200
MSDS
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