G-479 [1168092-22-5]

MedChem Express

G-479 [1168092-22-5]

5

1168092-22-5

Research Use Only

C16H15FIN5O4

487.22

G-479 is the inhibitor for MEK and hERG channel (IC50=14 microM). G-479 inhibits the proliferation of HCT-116 and A375 with IC50 of 0.049 microM and 0.004 microM. G-479 exhibits good metabolic stability in liver microsomes and good pharmacokinetic characteristics in rats[1].

O=C(C1=C(NC2=CC=C(I)C=C2F)N3C(C=N1)=CN=C3)NOC[C@H](O)CO

12352200