G907 [2244035-16-1]

MedChem Express

G907 [2244035-16-1]

9

2244035-16-1

Research Use Only

98.06

C26H24ClNO3

433.93

G907 is a selective antagonist of ATP-binding cassette (ABC) transporter MsbA with anti-microbial activity. G907 inhibits E. coli MsbA with an IC50 value of 18 nM. G907 traps MsbA in an inward-facing, lipopolysaccharide-bound conformation by wedging into an architecturally conserved transmembrane pocket[1][2].

O=C(O)/C=C/C1=C(C2CC2)C3=CC(OC(C4=C(C5CC5)C=CC=C4Cl)C)=CC=C3N=C1

-20°C,2°C to 8°C

12352200