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ProductsBack/GA-017 [2351906-74-4]
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GA-017 [2351906-74-4]

Research Use Only
T60013
TargetMol Chemicals
Molecular Weight343.38
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Product group Chemicals
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    GA-017 [2351906-74-4]
  • Delivery Days Customer
    9
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    GA-017
  • Molecular Formula
    C18H21N3O4
  • Molecular Weight
    343.38
  • Scientific Description
    GA-017 is a potent, selective inhibitor of LATS1 and LATS2 (large tumor suppressor kinase 1/2), exhibiting IC50 values of 4.10 and 3.92 nM, respectively. This compound simultaneously acts as an activator of cell proliferation by promoting YAP/TAZ activation and their nuclear translocation. Additionally, GA-017 enhances cell growth in 3D culture conditions and augments the ex vivo formation of mouse intestinal organoids [1].
  • Shelf life instruction
    3 years
  • SMILES
    CC\C(=N\NC(=O)NCc1cccc(O)c1)c1ccc(O)c(C)c1O
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Aihara A, et al. Small molecule LATS kinase inhibitors block the Hippo signaling pathway and promote cell growth under 3D culture conditions. J Biol Chem. 2022 Apr;298(4):101779.
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