GABAA receptor modular-3 [3021554-08-2]

TargetMol Chemicals

GABAA receptor modular-3 [3021554-08-2]

9

Research Use Only

Compound S28, also known as GABAA receptor modulator-3, regulates the (gamma-aminobutyric acid)A receptor (GABAA receptor), exhibiting EC50 values of 56 nM for the alpha1beta2gamma2 subtype and 10 nM for the alpha4beta3delta subtype. In rats, it demonstrates favorable pharmacokinetic properties and slight toxicity. The threshold dose for loss of righting reflex (LORR) in rats is 23.3 micromol/kg. Furthermore, Compound S28 shows potential to alleviate postpartum depression.

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