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gamma Sarcoglycan antibody

Name: gamma Sarcoglycan antibody
SKU: GTX117176_G10
Availability: BackOrder

GTX117176

ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin

Product group Antibodies

TargetSGCG

Overview

Supplier
GeneTex
Product Name
gamma Sarcoglycan antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
1 mg/ml
Conjugate
Unconjugated
Gene ID6445
Target name
SGCG
Target description
sarcoglycan gamma
Target synonyms
35DAG, A4, DAGA4, DMDA, DMDA1, LGMD2C, LGMDR5, MAM, SCARMD2, gamma-SG, gamma-sarcoglycan, 35 kDa dystrophin-associated glycoprotein, 35kD dystrophin-associated glycoprotein, sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
Host
Rabbit
Isotype
IgG
Protein IDQ13326
Protein Name
Gamma-sarcoglycan
Scientific Description
This gene encodes gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin. The dystrophin-glycoprotein complex (DGC) spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C). [provided by RefSeq, Oct 2008]
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Mamsa H, Stark RL, Shin KM, et al. Sarcospan increases laminin-binding capacity of α-dystroglycan to ameliorate DMD independent of Galgt2. Hum Mol Genet. 2022,31(5):718-732. doi: 10.1093/hmg/ddab276
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Perez-Ortiz AC, Peralta-Ildefonso MJ, Lira-Romero E, et al. Lack of Delta-Sarcoglycan (Sgcd) Results in Retinal Degeneration. Int J Mol Sci. 2019,20(21). doi: 10.3390/ijms20215480
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Estrada-Mena FJ, Rodriguez A, Mendoza-Lorenzo P, et al. Effects of (-)-epicatechin on frontal cortex DAPC and dysbindin of the mdx mice. Neurosci Lett. 2017,658:142-149. doi: 10.1016/j.neulet.2017.08.056
Read this paper