GATA4-NKX2-5-IN-1 [544681-96-1]

MedChem Express

GATA4-NKX2-5-IN-1 [544681-96-1]

10

544681-96-1

Research Use Only

99.24

C21H23N3O2

349.43

GATA4-NKX2-5-IN-1 (Compound 3) dose-dependently inhibits the GATA4-NKX2-5 transcriptional synergy with an IC50 of 3 microM. GATA4-NKX2-5-IN-1 exhibits no activity on the protein kinases involved in the regulation of GATA4 phosphorylation, and it modulates the hypertrophic agonist-induced cardiac gene expression[1].

CC1=C(C(NC2=CC=C(N(CC)CC)C=C2)=O)C(C3=CC=CC=C3)=NO1

-20°C,2°C to 8°C

12352200