GB1107

AbMole BioScience

GB1107

9

1978336-61-6

Chemical

Research Use Only

C20H16Cl2F3N3O4S

522.32

GB1107 is a potent, selective, orally active galectin-3 inhibitor with Kd of 37 nM. GB1107 inhibits lung adenocarcinoma growth and augments response to PD-L1 blockade. GB1107 potentiates the effects of a PD-L1 immune checkpoint inhibitor to increase expression of cytotoxic (IFN-gamma, granzyme B, perforin-1, Fas ligand) and apoptotic (cleaved caspase-3) effector molecules.

OCC1OC(SC2=CC=C(Cl)C(=C2)Cl)C(O)C(C1O)[N]3C=C(N=N3)C4=CC(=C(F)C(=C4)F)F

-20°C, dry, sealed

12352200